Isa was explicitly mentioned in the Holy Qur’an on sixteen different occasions. On one occasion, Allah the Exalted said: [The Day] when Allah will say, ‘O Jesus, Son of Mary, remember My favor upon you and upon your mother when I supported you with the Pure Spirit and you spoke to the people in the cradle and in maturity. And [remember] when I taught you writing and wisdom and the Torah and the Gospel. And when you designed from clay [what was] like the form of a bird with My permission, then you breathed into it, and it became a bird with My permission. And you healed the blind and the leper with My permission, and when you brought forth the dead with My permission. And when I restrained the Children of Israel from [killing] you when you came to them with clear proofs, and those who disbelieved among them said, ‘This is not but obvious magic.’ (5:110)
On the other hand, the Prophet Muhammad was only explicitly mentioned in the Holy Qur’an four times, whereas the Virgin Mary, the mother of Jesus, was mentioned eight times and has a complete Sura (chapter) named after her
On one occasion Allah the All Mighty said: [And mention] when the angels said, ‘O Mary, indeed Allah gives you good tidings of a word from Him, whose name will be the Messiah, Jesus, the son of Mary - distinguished in this world and the Hereafter and among those brought near [to Allah].’ (3:45)
As a family, they have been mentioned in the Holy Qur’an three times and they have been privileged by having a complete Sura (chapter) named after them (Aali Imran) which is imprinted in the hearts and minds of the believers forever